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Clinical Trials

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TACL Open Clinical Trials

Click to read a summary of each clinical trial. These summaries are intended to provide an overview of the open clinical trials being conducted by the Therapeutic Advances in Childhood Leukemia & Lymphoma consortium. They will provide general information about why the study is being done, the children that are eligible, and basic information about the treatment. The informed consent and protocol contain the full details of the study. Those documents are available from a doctor who is participating in the study. To find institutions and physicians who offer these trials please click here.

T2012-002
A Pilot Study of Vincristine Sulfate Liposome Injection (Marqibo®) in Combination with UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults with Relapse of Acute Lymphoblastic Leukemia (IND 128316)
T2017-002
A TACL Phase 1/2 Study of PO Ixazomib in Combination with Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma IND# 140730
T2020-004
Risk stratified treatment for patients with newly diagnosed juvenile myelomonocytic leukemia: A Phase I/II non-randomized study of trametinib and azacitidine with or without chemotherapy IND #164058
T2020-003
A Phase 2 Randomized Trial of Caloric Restriction and Activity to Reduce Chemoresistance in B-Cell Acute Lymphoblastic Leukemia (IDEAL2)
T2020-006
A Phase I Study of Tagraxofusp With or Without Chemotherapy in Pediatric Patients with Relapsed or Refractory CD123 Expressing Hematologic Malignancies